Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α.

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作者： Ashuei,Sogawa ^[1] ; Ryota,Komori ^[2] ; Kota,Yanagitani ^[3] ; Miku,Ohfurudono ^[4] ; Akio,Tsuru ^[5] ; Koji,Kadoi ^[6] ; Yukio,Kimata ^[7] ; Hiderou,Yoshida ^[8] ; Kenji,Kohno ^[9]

作者单位： Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST).;Osaka International Cancer Institute (OICI). ^[1] Institute for Research Initiatives, Nara Institute of Science and Technology (NAIST).;Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST).;Department of Biochemistry and Molecular Biology, Graduate School of Science, University of Hyogo. ^[2] Institute for Research Initiatives, Nara Institute of Science and Technology (NAIST).;Ubiquitin Biology Laboratory, Graduate School of Frontier Biosciences, Osaka University. ^[3] Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST).;Institute for Research Initiatives, Nara Institute of Science and Technology (NAIST). ^[4] Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST).;Institute for Research Initiatives, Nara Institute of Science and Technology (NAIST).;Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST). ^[5] Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST). ^[6] Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST).;Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST). ^[7] Department of Biochemistry and Molecular Biology, Graduate School of Science, University of Hyogo. ^[8] Laboratory of Molecular and Cell Genetics, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST).;Institute for Research Initiatives, Nara Institute of Science and Technology (NAIST).;Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST).;Department of Biochemistry and Molecular Biology, Graduate School of Science, University of Hyogo. ^[9]

关键词 IRE1 endoplasmic reticulum signal sequence translocation capacity translocon clogging

主题词动物(Animals);内切核糖核酸酶类(Endoribonucleases);蛋白分选信号(Protein Sorting Signals);伤病员分拣(Triage);哺乳动物(Mammals)

DOI 10.1247/csf.23072

PMID 37766570

发布时间 2024-10-25

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