Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.

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作者： Stephanie L,Smith-Roe ^[1] ; Cheryl A,Hobbs ^[2] ; Victoria,Hull ^[2] ; J,Todd Auman ^[2] ; Leslie,Recio ^[2] ; Michael A,Streicker ^[2] ; Miriam V,Rivas ^[2] ; Gabriel A,Pratt ^[3] ; Fang Yin,Lo ^[3] ; Jacob E,Higgins ^[3] ; Elizabeth K,Schmidt ^[3] ; Lindsey N,Williams ^[3] ; Daniela,Nachmanson ^[3] ; Charles C,Valentine Iii ^[3] ; Jesse J,Salk ^[3] ; Kristine L,Witt ^[4]

作者单位： Division of Translational Toxicology, NIEHS, Research Triangle Park, NC, USA. Electronic address: stephanie.smith-roe@nih.gov. ^[1] Integrated Laboratory Systems, LLC (An Inotiv Company), Research Triangle Park, NC, USA. ^[2] TwinStrand Biosciences, Inc., Seattle, WA, USA. ^[3] Division of Translational Toxicology, NIEHS, Research Triangle Park, NC, USA. ^[4]

关键词 DuplexSeq?EcNGS Error-corrected NGS Pig-a gene mutation assay Rat-50 mutagenesis assay Transgenic rodent assay

主题词大鼠(Rats);男(雄)性(Male);动物(Animals);乙基亚硝脲(Ethylnitrosourea);结果可重复性(Reproducibility of Results);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);诱变(Mutagenesis);突变(Mutation);亚硝基脲化合物(Nitrosourea Compounds);诱变剂(Mutagens)

DOI 10.1016/j.mrgentox.2023.503669

PMID 37770135

发布时间 2024-10-03

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Mutation research. Genetic toxicology and environmental mutagenesis

2023年891卷

503669页

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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.

Mutation research. Genetic toxicology and environmental mutagenesis

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Mutation research. Genetic toxicology and environmental mutagenesis

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Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.

Mutation research. Genetic toxicology and environmental mutagenesis

相似文献

Mutation research. Genetic toxicology and environmental mutagenesis

相关期刊

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