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Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels.

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第一作者： Murielle,Golomingi

第一单位： Experimental Haemostasis Group, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.

作者： Murielle,Golomingi ^[1] ; Jessie,Kohler ^[1] ; Christina,Lamers ^[2] ; Richard B,Pouw ^[2] ; Daniel,Ricklin ^[2] ; József,Dobó ^[3] ; Péter,Gál ^[3] ; Gábor,Pál ^[4] ; Bence,Kiss ^[4] ; Arthur,Dopler ^[5] ; Christoph Q,Schmidt ^[5] ; Elaissa Trybus,Hardy ^[6] ; Wilbur,Lam ^[6] ; Verena,Schroeder ^[1]

作者单位： Experimental Haemostasis Group, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. ^[1] Molecular Pharmacy Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. ^[2] Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary. ^[3] Department of Biochemistry, Eötvös Loránd University, Budapest, Hungary. ^[4] Institute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, Ulm, Germany. ^[5] Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.;Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, United States.;Department of Pediatrics, Emory University, Atlanta, GA, United States. ^[6]

关键词 MBL-associated serine protease-2 (MASP-2)complement C1s complement C3 complement C5 complement factor D (FD)complement system haemostasis microfluidics