Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion.

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第一作者： Xushen,Xiong

第一单位： Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China.

作者： Xushen,Xiong ^[1] ; Benjamin T,James ^[2] ; Carles A,Boix ^[2] ; Yongjin P,Park ^[3] ; Kyriaki,Galani ^[2] ; Matheus B,Victor ^[4] ; Na,Sun ^[2] ; Lei,Hou ^[2] ; Li-Lun,Ho ^[2] ; Julio,Mantero ^[2] ; Aine Ni,Scannail ^[4] ; Vishnu,Dileep ^[4] ; Weixiu,Dong ^[5] ; Hansruedi,Mathys ^[6] ; David A,Bennett ^[7] ; Li-Huei,Tsai ^[8] ; Manolis,Kellis ^[9]

作者单位： Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China. ^[1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. ^[2] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Pathology and Laboratory Medicine, Department of Statistics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. ^[3] Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[4] Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. ^[5] Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ^[6] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA. ^[7] The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: lhtsai@mit.edu. ^[8] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: manoli@mit.edu. ^[9]

关键词 ATAC-QTL Alzheimer’s disease GWAS epigenome epigenome erosion fine-mapping multimodal integration peak-to-gene linking

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);脑(Brain);表观基因组学(Epigenomics);基因表达调控(Gene Expression Regulation);全基因组关联研究(Genome-Wide Association Study)

DOI 10.1016/j.cell.2023.08.040

PMID 37774680

发布时间 2024-11-14

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