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Loss of p53 and mutational heterogeneity drives immune resistance in an autochthonous mouse lung cancer model with high tumor mutational burden.

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第一作者： Mingrui,Zhu

第一单位： Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, Dallas, TX, USA.

作者： Mingrui,Zhu ^[1] ; Jiwoong,Kim ^[2] ; Qing,Deng ^[1] ; Biagio,Ricciuti ^[3] ; Joao V,Alessi ^[3] ; Buse,Eglenen-Polat ^[1] ; Matthew E,Bender ^[1] ; Hai-Cheng,Huang ^[1] ; Ryan R,Kowash ^[1] ; Ileana,Cuevas ^[1] ; Zachary T,Bennett ^[4] ; Jinming,Gao ^[5] ; John D,Minna ^[6] ; Diego H,Castrillon ^[1] ; Mark M,Awad ^[3] ; Lin,Xu ^[7] ; Esra A,Akbay ^[8]

作者单位： Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, Dallas, TX, USA. ^[1] Quantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[2] Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[3] Simmons Comprehensive Cancer Center, Dallas, TX, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[4] Simmons Comprehensive Cancer Center, Dallas, TX, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[5] Simmons Comprehensive Cancer Center, Dallas, TX, USA; Department Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[6] Quantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[7] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Simmons Comprehensive Cancer Center, Dallas, TX, USA. Electronic address: esra.akbay@utsouthwestern.edu. ^[8]

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