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Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality.

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作者单位: McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [1] McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.;Department of Natural Sciences, College of Arts and Sciences, Bowie State University, Bowie, MD, USA. [2] Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. [3] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. [4] Department of Genetics, Yale School of Medicine, New Haven, CT, USA.;Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC, Australia. [5] Department of Genetics, Yale School of Medicine, New Haven, CT, USA. [6] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [7] Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. [8] Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. [9] Division of Biostatistics, Institute for Health & Equity, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA. [10] Departments of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Framingham Heart Study, Framingham, MA, USA. [11] Framingham Heart Study, Framingham, MA, USA.;Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA. [12] Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA. [13] Section of General Internal Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. [14] National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. [15] Human Genetics Center; Department of Epidemiology, Human Genetics, and Environmental Sciences; School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. [16] Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. [17] Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. [18] Division of Hematological Malignancies, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. [19] Department of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. [20] McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. arking@jhmi.edu. [21]
DOI 10.1038/s41467-023-41785-7
PMID 37777527
发布时间 2024-09-23
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