Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.

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第一作者： Yiqing,Cai

第一单位： Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, China.

作者： Yiqing,Cai ^[1] ; Xiaomin,Chen ^[1] ; Tiange,Lu ^[1] ; Xiaosheng,Fang ^[2] ; Mengfei,Ding ^[1] ; Zhuoya,Yu ^[1] ; Shunfeng,Hu ^[1] ; Jiarui,Liu ^[1] ; Xiangxiang,Zhou ^[2] ; Xin,Wang ^[3]

作者单位： Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, China. ^[1] Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.;Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, 250021, China.;Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, 250021, China.;National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, 251006, China. ^[2] Department of Hematology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, China.;Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.;Shandong Provincial Engineering Research Center of Lymphoma, Jinan, Shandong, 250021, China.;Branch of National Clinical Research Center for Hematologic Diseases, Jinan, Shandong, 250021, China.;National Clinical Research Center for Hematologic Diseases, the First Affiliated Hospital of Soochow University, Suzhou, 251006, China. ^[3]

关键词 DLBCL DMXAA.PANoptosis SAMHD1 STING

主题词人类(Humans);DNA(DNA);淋巴瘤, 大B细胞, 弥漫性(Lymphoma, Large B-Cell, Diffuse);核苷酸基转移酶类(Nucleotidyltransferases);磷酰化(Phosphorylation)

DOI 10.7150/ijbs.85236

PMID 37781035

发布时间 2023-10-03

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