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SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B.

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作者单位: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [1] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. [2] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. [3] CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. [4] University of Chinese Academy of Sciences, Beijing, China. [5] Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. [6] School of Biomedical Sciences, Hunan University, Changsha, China. [7] Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China. [8] Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing, China. [9] State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. [10] Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. [11] Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China. [12] The Fifth People's Hospital of Chongqing, Chongqing, China. [13] State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. [14] Altos Labs, Inc., San Diego, CA, USA. [15] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn. [16] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn. [17] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. qujing@ioz.ac.cn. [18] University of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn. [19] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. zhangwq@big.ac.cn. [20] CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China. zhangwq@big.ac.cn. [21] University of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn. [22] Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn. [23] Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn. [24] Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn. [25] University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn. [26] State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn. [27] Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn. [28] Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China. ghliu@ioz.ac.cn. [29]
DOI 10.1038/s43587-023-00486-y
PMID 37783815
发布时间 2024-05-23
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Nature aging

Nature aging

2023年3卷10期

1269-1287页

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