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Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection.

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第一作者： Sreekar,Mantena

第一单位： Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Statistics, Harvard University, Cambridge, MA, USA.;Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

作者： Sreekar,Mantena ^[1] ; Priya P,Pillai ^[2] ; Brittany A,Petros ^[3] ; Nicole L,Welch ^[2] ; Cameron,Myhrvold ^[4] ; Pardis C,Sabeti ^[5] ; Hayden C,Metsky ^[2]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Statistics, Harvard University, Cambridge, MA, USA.;Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA, USA.;Harvard/Massachusetts Institute of Technology, MD-PhD Program, Boston, MA, USA.;Department of Systems Biology, Harvard Medical School, Boston, MA, USA. ^[3] Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ^[4] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.;Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.;Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. ^[5]

DOI 10.1101/2023.09.20.557569

PMID 37786711

发布时间 2025-08-12

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Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection.

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Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection.

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