Factors contributing to the nonlinear pharmacokinetics of astegolimab: a close examination of potential causes.

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第一作者： Gizette,Sperinde

第一单位： BioAnalytical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA.

作者： Gizette,Sperinde ^[1] ; Michael,Dolton ^[2] ; Wenhui,Zhang ^[2] ; Joel,Mathews ^[3] ; Wendy,Putnam ^[4] ; Saloumeh K,Fischer ^[1]

作者单位： BioAnalytical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA. ^[1] Clinical Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, USA. ^[2] Biomarker Research, Ionis Pharmaceuticals, 2855 Gazelle Ct, Carlsbad, CA 92010, USA. ^[3] 60 Leveroni Ct, Novato, CA 94949, USA. ^[4]

关键词 free PK assay non-linear PK target-mediated drug disposition total PK assay

主题词模型, 生物学(Models, Biological);药物释放系统(Drug Delivery Systems);生物学鉴定法(Biological Assay)

DOI 10.4155/bio-2023-0115

PMID 37791725

发布时间 2023-11-01

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准确一般字义偏差语意偏离译文作用小提交