Design and Synthesis of Novel 2-Acetamido, 6-Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors - In vitro Evaluation of their Antiproliferative Activity.

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作者： Yakinthi,Batsi ^[1] ; Georgia,Antonopoulou ^[1] ; Theano,Fotopoulou ^[1] ; Kassandra,Koumaki ^[1] ; Eftichia,Kritsi ^[1] ; Constantinos,Potamitis ^[1] ; Maria,Goulielmaki ^[1] ; Salomi,Skarmalioraki ^[1] ; Chara,Papalouka ^[1] ; Eleni,Poulou-Sidiropoulou ^[1] ; Vivian,Kosmidou ^[1] ; Stavroula,Douna ^[1] ; Maria-Sofia,Vidali ^[1] ; Eleni-Fani,Gkotsi ^[1] ; Aristotelis,Chatziioannou ^[1] ; Vassilis L,Souliotis ^[1] ; Vasiliki,Pletsa ^[1] ; Olga,Papadodima ^[1] ; Vassilis,Zoumpourlis ^[1] ; Panagiotis,Georgiadis ^[1] ; Maria,Zervou ^[1] ; Alexander,Pintzas ^[1] ; Ioannis D,Kostas ^[1]

作者单位： Institute of Chemical Biology, National Hellenic Research Foundation, Vas. Constantinou Ave. 48, 11635, Athens, Greece. ^[1]

关键词 BRAFV600E inhibitors Benzothiazole Cancer In silico studies In vitro biological evaluation

主题词细胞系, 肿瘤(Cell Line, Tumor);苯并噻唑类(Benzothiazoles);抗肿瘤药(Antineoplastic Agents);细胞增殖(Cell Proliferation);构效关系(Structure-Activity Relationship);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor)

DOI 10.1002/cmdc.202300322

PMID 37792577

发布时间 2024-03-26

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