Polyphosphate coated nanoparticles: Enzyme-activated charge-reversal gene delivery systems.

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作者： Zeynep Burcu,Akkuş-Dağdeviren ^[1] ; Sema,Arısoy ^[2] ; Julian David,Friedl ^[1] ; Andrea,Fürst ^[1] ; Ahmad,Saleh ^[3] ; Andreas,Bernkop-Schnürch ^[4]

作者单位： Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. ^[1] Department of Pharmaceutical Technology, Selcuk University, Faculty of Pharmacy, Konya, Turkey. ^[2] Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria; Department of Pharmacy, Universitas Mandala Waluya, A.H. Nasution, Kendari 93231, Southeast Sulawesi, Republic of Indonesia. ^[3] Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria. Electronic address: andreas.bernkop@uibk.ac.at. ^[4]

关键词 Charge-reversal Gene delivery Lipid nanoparticles Polyphosphate coating Protamine Transfection

主题词人类(Humans);基因转移技术(Gene Transfer Techniques);质粒(Plasmids);转染(Transfection);DNA(DNA);纳米粒子(Nanoparticles);鱼精蛋白类(Protamines)

DOI 10.1016/j.ijpharm.2023.123474

PMID 37793466

发布时间 2023-10-31

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