换一批European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
第一作者：
Ashley,Budu-Aggrey
第一单位：
Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
作者：
Ashley,Budu-Aggrey [1]
;
Anna,Kilanowski [2]
;
Maria K,Sobczyk [1]
;
23andMe Research Team [3]
;
Suyash S,Shringarpure [1]
;
Ruth,Mitchell [4]
;
Kadri,Reis [4]
;
Anu,Reigo [4]
;
Estonian Biobank Research Team [5]
;
Reedik,Mägi [6]
;
Mari,Nelis [7]
;
Nao,Tanaka [8]
;
Ben M,Brumpton [9]
;
Laurent F,Thomas [9]
;
Pol,Sole-Navais [10]
;
Christopher,Flatley [10]
;
Antonio,Espuela-Ortiz [11]
;
Esther,Herrera-Luis [11]
;
Jesus V T,Lominchar [12]
;
Jette,Bork-Jensen [12]
;
Ingo,Marenholz [13]
;
Aleix,Arnau-Soler [14]
;
Ayoung,Jeong [15]
;
Katherine A,Fawcett [16]
;
Hansjorg,Baurecht [17]
;
Elke,Rodriguez [18]
;
Alexessander Couto,Alves [19]
;
Ashish,Kumar [20]
;
Patrick M,Sleiman [21]
;
Xiao,Chang [22]
;
Carolina,Medina-Gomez [23]
;
Chen,Hu [24]
;
Cheng-Jian,Xu [25]
;
Cancan,Qi [25]
;
Sarah,El-Heis [26]
;
Philip,Titcombe [27]
;
Elie,Antoun [28]
;
João,Fadista [29]
;
Carol A,Wang [30]
;
Elisabeth,Thiering [31]
;
Baojun,Wu [32]
;
Sara,Kress [33]
;
Dilini M,Kothalawala [34]
;
Latha,Kadalayil [34]
;
Jiasong,Duan [35]
;
Hongmei,Zhang [36]
;
Sabelo,Hadebe [37]
;
Thomas,Hoffmann [38]
;
Eric,Jorgenson [36]
;
Hélène,Choquet [39]
;
Neil,Risch [40]
;
Pål,Njølstad [41]
;
Ole A,Andreassen [42]
;
Stefan,Johansson [43]
;
Catarina,Almqvist [43]
;
Tong,Gong [43]
;
Vilhelmina,Ullemar [43]
;
Robert,Karlsson [43]
;
Patrik K E,Magnusson [44]
;
Agnieszka,Szwajda [45]
;
Esteban G,Burchard [11]
;
Jacob P,Thyssen [46]
;
Torben,Hansen [46]
;
Line L,Kårhus [12]
;
Thomas M,Dantoft [12]
;
Alexander C S N,Jeanrenaud [47]
;
Ahla,Ghauri [48]
;
Andreas,Arnold [49]
;
Georg,Homuth [50]
;
Susanne,Lau [51]
;
Markus M,Nöthen [13]
;
Norbert,Hübner [52]
;
Medea,Imboden [52]
;
Alessia,Visconti [53]
;
Mario,Falchi [52]
;
Veronique,Bataille [18]
;
Pirro,Hysi [54]
;
Natalia,Ballardini [55]
;
Dorret I,Boomsma [56]
;
Jouke J,Hottenga [57]
;
Martina,Müller-Nurasyid [58]
;
Tarunveer S,Ahluwalia [59]
;
Jakob,Stokholm [58]
;
Bo,Chawes [60]
;
Ann-Marie M,Schoos [61]
;
Ana,Esplugues [62]
;
Mariona,Bustamante [63]
;
Benjamin,Raby [3]
;
Syed,Arshad [4]
;
Chris,German [4]
;
Tõnu,Esko [4]
;
Lili A,Milani [64]
;
Andres,Metspalu [65]
;
Chikashi,Terao [66]
;
Katrina,Abuabara [67]
;
Mari,Løset [68]
;
Kristian,Hveem [69]
;
Bo,Jacobsson [70]
;
Maria,Pino-Yanes [11]
;
David P,Strachan [71]
;
Niels,Grarup [12]
;
Allan,Linneberg [13]
;
Young-Ae,Lee [72]
;
Nicole,Probst-Hensch [73]
;
Stephan,Weidinger [18]
;
Marjo-Riitta,Jarvelin [74]
;
Erik,Melén [75]
;
Hakon,Hakonarson [76]
;
Alan D,Irvine [77]
;
Deborah,Jarvis [78]
;
Tamar,Nijsten [79]
;
Liesbeth,Duijts [24]
;
Judith M,Vonk [80]
;
Gerard H,Koppelmann [25]
;
Keith M,Godfrey [81]
;
Sheila J,Barton [28]
;
Bjarke,Feenstra [82]
;
Craig E,Pennell [83]
;
Peter D,Sly [30]
;
Patrick G,Holt [59]
;
L Keoki,Williams [59]
;
Hans,Bisgaard [84]
;
Klaus,Bønnelykke [84]
;
John,Curtin [84]
;
Angela,Simpson [85]
;
Clare,Murray [86]
;
Tamara,Schikowski [62]
;
Supinda,Bunyavanich [87]
;
Scott T,Weiss [1]
;
John W,Holloway [88]
;
Josine L,Min [89]
;
Sara J,Brown [90]
;
Marie,Standl ;
Lavinia,Paternoster
作者单位：
Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
[1]
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.;Pettenkofer School of Public Health, Ludwig-Maximilians University Munich, Munich, Germany.
[2]
23andMe, Inc., Sunnyvale, CA, USA.
[3]
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
[4]
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.;Core Facility of Genomics, University of Tartu, Tartu, Estonia.
[5]
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
[6]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.;HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway.;Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, 7030, Norway.
[7]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.;Department of Clinical and Molecular Medicine, NTNU Norwegian University of Science and Technology, Trondheim, Norway.;BioCore - Bioinformatics Core Facility, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
[8]
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
[9]
Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.
[10]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, København, Denmark.
[11]
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.;Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
[12]
Swiss Tropical and Public Health Institute, CH-4123, Basel, Switzerland.;University of Basel, CH-4001, Basel, Switzerland.
[13]
Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.
[14]
Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
[15]
Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany.
[16]
School of Biosciences and Medicine, University of Surrey, Guildford, UK.
[17]
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Solna, Sweden.
[18]
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.;Rhythm Pharmaceuticals, 222 Berkley Street, Boston, 02116, USA.
[19]
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
[20]
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[21]
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[22]
University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands.;University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.;Centre for Individualized Infection Medicine, CiiM, a joint venture between Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.;TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
[23]
University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, Groningen, The Netherlands.;University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.
[24]
MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
[25]
Faculty of Medicine, University of Southampton, Southampton, UK.;Institute of Developmental Sciences, University of Southampton, Southampton, UK.
[26]
Department of Bioinformatics & Data Mining, Måløv, Denmark.;Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.;Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
[27]
School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.;Hunter Medical Research Institute, Newcastle, NSW, Australia.
[28]
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
[29]
Center for Individualized and Genomic Medicine Research (CIGMA), Department of Medicine, Henry Ford Health, Detroit, MI, 48104, USA.
[30]
Environmental Epidemiology of Lung, Brain and Skin Aging, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
[31]
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.;NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
[32]
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
[33]
Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
[34]
Division of Immunology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
[35]
Institute for Human Genetics, UCSF, San Francisco, CA, 94143, USA.;Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, 94158, USA.
[36]
Regeneron Genetics Center, Tarrytown, NY, USA.
[37]
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
[38]
Center for Diabetes Research, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.;Children and Youth Clinic, Haukeland University Hospital, NO-5021, Bergen, Norway.
[39]
NORMENT Centre, Institute of Clinical Medicine, University of Oslo, 0450, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, 0450, Oslo, Norway.
[40]
Center for Diabetes Research, Department of Clinical Science, University of Bergen, NO-5020, Bergen, Norway.;Department of Medical Genetics, Haukeland University Hospital, NO-5021, Bergen, Norway.
[41]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Pediatric Lung and Allergy Unit, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
[42]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
[43]
Department of Medicine, University of California San Francisco, San Francisco, CA, USA.;Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
[44]
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
[45]
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
[46]
Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
[47]
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
[48]
Department of Pediatric Respiratory Medicine, Immunology, and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
[49]
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
[50]
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.;Charite-Universitätsmedizin Berlin, Berlin, Germany.
[51]
Department of Twin Research & Genetics Epidemiology, Kings College London, London, UK.
[52]
Department of Twin Research & Genetics Epidemiology, Kings College London, London, UK.;Dermatology Department, West Herts NHS Trust, Watford, UK.
[53]
Dept Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands.;Institute for Health and Care Research (EMGO), VU University, Amsterdam, the Netherlands.
[54]
Dept Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands.
[55]
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;IBE, Faculty of Medicine, LMU Munich, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
[56]
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.;Steno Diabetes Center Copenhagen, Herlev, Denmark.;Department of Biology, University of Copenhagen, Copenhagen, Denmark.
[57]
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.;Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark.
[58]
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
[59]
Nursing School, University of Valencia, FISABIO-University Jaume I-University of Valencia, Valencia, Spain.;Joint Research Unit of Epidemiology and Environmental Health, CIBERESP, Valencia, Spain.
[60]
ISGlobal, Institute for Global Health, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.;CIBER Epidemiología y Salud Pública, Madrid, Spain.
[61]
Channing Division of Network Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
[62]
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.;David Hide Asthma and Allergy Research Centre, Isle of Wight, UK.
[63]
Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.;Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan.;Department of Applied Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
[64]
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.
[65]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.;Department of Dermatology, Clinic of Orthopaedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
[66]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, 7030, Norway.;HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
[67]
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.;Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.
[68]
Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Tenerife, Spain.;CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.;Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
[69]
Population Health Research Institute, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
[70]
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[71]
Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein, Kiel, Germany.
[72]
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health,Imperial College London, London, UK.;Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.;Biocenter Oulu, University of Oulu, Oulu, Finland.
[73]
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.;Department of Pediatrics, Divisions of Human Genetics and Pulmonary Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.;Faculty of Medicine, University of Iceland, 101, Reykjavík, Iceland.
[74]
Department of Clinical Medicine, Trinity College, Dublin, Ireland.
[75]
Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom.;Medical Research Council and Public Health England Centre for Environment and Health, London, United Kingdom.
[76]
Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[77]
Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Pediatrics, division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[78]
University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.;University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
[79]
MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
[80]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[81]
Children's Health and Environment Program, Child Health Research Centre, The University of Queensland, South Brisbane, 4101, Queensland, Australia.;Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, 4072, QLD, Australia.
[82]
Telethon Kids Institute, University of Western Australia, Perth, WA, Australia.
[83]
Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, England.
[84]
Environmental Epidemiology of Lung, Brain and Skin Aging, Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
[85]
Division of Allergy and Immunology, Department of Pediatrics, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[86]
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.;Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
[87]
Centre for Genomics and Experimental Medicine, Institute for Genetics and Cancer, University of Edinburgh, Crewe Road, Edinburgh, UK EH4 2XU, Scotland.
[88]
Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Lung Research (DZL), Munich, Germany.
[89]
Medical Research Council Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, England. l.paternoster@bristol.ac.uk.;Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England. l.paternoster@bristol.ac.uk.
[90]
医学主题词
人类(Humans);全基因组关联研究(Genome-Wide Association Study);皮炎, 特应性(Dermatitis, Atopic);疾病遗传易感性(Genetic Predisposition to Disease);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1038/s41467-023-41180-2
PMID
37794016
发布时间
2025-05-30
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Nature communications
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