Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
作者:
Robin N,Beaumont [1]
;
Christopher,Flatley [2]
;
Marc,Vaudel [3]
;
Xiaoping,Wu [4]
;
Jing,Chen [5]
;
Gunn-Helen,Moen [6]
;
Line,Skotte [4]
;
Øyvind,Helgeland [7]
;
Pol,Solé-Navais [8]
;
Karina,Banasik [9]
;
Clara,Albiñana [10]
;
Justiina,Ronkainen [11]
;
João,Fadista [12]
;
Sara Elizabeth,Stinson [13]
;
Katerina,Trajanoska [14]
;
Carol A,Wang [15]
;
David,Westergaard [16]
;
Sundararajan,Srinivasan [17]
;
Carlos,Sánchez-Soriano [18]
;
Jose Ramon,Bilbao [19]
;
Catherine,Allard [20]
;
Marika,Groleau [21]
;
Teemu,Kuulasmaa [22]
;
Daniel J,Leirer [1]
;
Frédérique,White [21]
;
Pierre-Étienne,Jacques [23]
;
Haoxiang,Cheng [24]
;
Ke,Hao [24]
;
Ole A,Andreassen [25]
;
Bjørn Olav,Åsvold [26]
;
Mustafa,Atalay [22]
;
Laxmi,Bhatta [27]
;
Luigi,Bouchard [28]
;
Ben Michael,Brumpton [29]
;
Søren,Brunak [9]
;
Jonas,Bybjerg-Grauholm [30]
;
Cathrine,Ebbing [31]
;
Paul,Elliott [32]
;
Line,Engelbrechtsen [33]
;
Christian,Erikstrup [34]
;
Marisa,Estarlich [35]
;
Stephen,Franks [36]
;
Romy,Gaillard [37]
;
Frank,Geller [4]
;
Jakob,Grove [38]
;
David M,Hougaard [30]
;
Eero,Kajantie [39]
;
Camilla S,Morgen [40]
;
Ellen A,Nohr [41]
;
Mette,Nyegaard [42]
;
Colin N A,Palmer [17]
;
Ole Birger,Pedersen [43]
;
Early Growth Genetics (EGG) Consortium [44]
;
Fernando,Rivadeneira [11]
;
Sylvain,Sebert [1]
;
Beverley M,Shields [45]
;
Camilla,Stoltenberg [46]
;
Ida,Surakka [47]
;
Lise Wegner,Thørner [48]
;
Henrik,Ullum [49]
;
Marja,Vaarasmaki [50]
;
Bjarni J,Vilhjalmsson [51]
;
Cristen J,Willer [52]
;
Timo A,Lakka [53]
;
Dorte,Gybel-Brask [54]
;
Mariona,Bustamante [13]
;
Torben,Hansen [17]
;
Ewan R,Pearson [18]
;
Rebecca M,Reynolds [55]
;
Sisse R,Ostrowski [15]
;
Craig E,Pennell [37]
;
Vincent W V,Jaddoe [37]
;
Janine F,Felix [1]
;
Andrew T,Hattersley [56]
;
Mads,Melbye [57]
;
Deborah A,Lawlor [58]
;
Kristian,Hveem [59]
;
Thomas,Werge [60]
;
Henriette Svarre,Nielsen [61]
;
Per,Magnus [62]
;
David M,Evans [2]
;
Bo,Jacobsson [63]
;
Marjo-Riitta,Järvelin [64]
;
Ge,Zhang [65]
;
Marie-France,Hivert [66]
;
Stefan,Johansson [67]
;
Rachel M,Freathy [68]
;
Bjarke,Feenstra [69]
;
Pål R,Njølstad
作者单位:
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
[1]
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.;Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
[2]
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
[3]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
[4]
Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
[5]
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.;Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia.;K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
[6]
Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.;Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
[7]
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
[8]
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
[9]
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
[10]
Research Unit of Population Health, University of Oulu, Oulu, Finland.
[11]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.;Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.;Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
[12]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[13]
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Human Genetics, McGill University, Montréal, Québec, Canada.
[14]
School of Medicine and Public Health, College of Medicine, Public Health and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia.;Hunter Medical Research Institute, New Lambton Heights, Newcastle, New South Wales, Australia.
[15]
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.;Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark.;Methods and Analysis, Statistics Denmark, Copenhagen, Denmark.
[16]
Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
[17]
Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
[18]
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.;Biobizkaia Health Research Institute, Barakaldo, Spain.;Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.
[19]
Centre de recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, Québec, Canada.
[20]
Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
[21]
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
[22]
Centre de recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, Québec, Canada.;Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
[23]
Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
[24]
NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
[25]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.;Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
[26]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
[27]
Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.;Clinical Department of Laboratory Medicine, Centre intégré universitaire de santé et de services sociaux (CIUSSS) du Saguenay-Lac-St-Jean-Hôpital Universitaire de Chicoutimi, Saguenay, Québec, Canada.
[28]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.;Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
[29]
Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.;iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
[30]
Department of Clinical Science, University of Bergen, Bergen, Norway.;Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
[31]
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
[32]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;Department of Obstetrics and Gynecology, Herlev Hospital, Herlev, Denmark.
[33]
Department Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.;Department Clinical Medicine, Aarhus University, Aarhus, Denmark.
[34]
Faculty of Nursing and Chiropody, Universitat de València, C/Menendez Pelayo, Valencia, Spain.;Epidemiology and Environmental Health Joint Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public Health, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.;Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
[35]
Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.
[36]
The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[37]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Department of Biomedicine-Human Genetics and the iSEQ Center, Aarhus University, Aarhus, Denmark.;Center for Genomics and Personalized Medicine, Aarhus, Denmark.;Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
[38]
Research Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, Finland.;Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.;Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
[39]
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.;National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
[40]
Institute of Clinical research, University of Southern Denmark, Odense, Denmark.
[41]
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
[42]
Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
[43]
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.;The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[44]
Norwegian Institute of Public Health, Oslo, Norway.;Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
[45]
Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
[46]
Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
[47]
Statens Serum Institut, Copenhagen, Denmark.
[48]
Research Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, Finland.;Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland.
[49]
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.;Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
[50]
Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.;Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.;Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
[51]
Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.;Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.;Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
[52]
Psychotherapeutic Outpatient Clinic, Mental Health Services, Capital Region, Copenhagen, Denmark.
[53]
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.;ISGlobal, Institute for Global Health, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.
[54]
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.;Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
[55]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.;Danish Cancer Institute, Copenhagen, Denmark.;Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
[56]
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.;Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
[57]
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.;HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
[58]
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.;Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.;Lundbeck Center for Geogenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
[59]
Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
[60]
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
[61]
Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.;Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
[62]
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.;Center for Life Course Health Research, University of Oulu, Oulu, Finland.;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.;Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.
[63]
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.;Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.;March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
[64]
Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.;Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
[65]
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. stefan.johansson@uib.no.;Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway. stefan.johansson@uib.no.
[66]
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. r.freathy@exeter.ac.uk.;Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK. r.freathy@exeter.ac.uk.
[67]
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fee@ssi.dk.;Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. fee@ssi.dk.
[68]
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. pal.njolstad@uib.no.;Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway. pal.njolstad@uib.no.
[69]
主题词
女(雌)性(Female);人类(Humans);妊娠(Pregnancy);出生体重(Birth Weight);胎儿发育(Fetal Development);全基因组关联研究(Genome-Wide Association Study);胰岛素(Insulin);胎盘(Placenta);男(雄)性(Male)
DOI
10.1038/s41588-023-01520-w
PMID
37798380
发布时间
2024-12-11
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Nature genetics
Nature genetics
1807-1819页
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