Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma.

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作者： Lucie,Thorel ^[1] ; Pierre-Marie,Morice ^[1] ; Hippolyte,Paysant ^[1] ; Romane,Florent ^[1] ; Guillaume,Babin ^[2] ; Cécilia,Thomine ^[3] ; Marion,Perréard ^[1] ; Edwige,Abeilard ^[4] ; Florence,Giffard ^[1] ; Emilie,Brotin ^[1] ; Christophe,Denoyelle ^[1] ; Céline,Villenet ^[3] ; Shéhérazade,Sebda ^[1] ; Mélanie,Briand ^[3] ; Florence,Joly ^[5] ; Enora,Dolivet ^[1] ; Didier,Goux ^[3] ; Cécile,Blanc-Fournier ^[5] ; Corinne,Jeanne ^[6] ; Marie,Villedieu ^[6] ; Matthieu,Meryet-Figuiere ^[1] ; Martin,Figeac ^[7] ; Laurent,Poulain ^[8] ; Louis-Bastien,Weiswald ^[1]

作者单位： Université de Caen Normandie, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France. ^[1] Université de Caen Normandie, Services Unit PLATON, ORGAPRED Core Facility, Caen, France. ^[2] UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France. ^[3] UNICANCER, Comprehensive Cancer Center Francois Baclesse, Department of Surgery, Caen, France. ^[4] Université de Caen Normandie, Services Unit PLATON, ImpedanCell Core Facility, Caen, France. ^[5] University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, Lille, France. ^[6] UNICANCER, Comprehensive Cancer Center Francois Baclesse, Biological Resources Center 'OvaRessources', Caen, France. ^[7] UNICANCER, Comprehensive Cancer Center Francois Baclesse, Clinical Research Department, Caen, France. ^[8] Université de Caen Normandie, Services Unit EMERODE, « Centre de Microscopie Appliquée À La Biologie » CMAbio3, Caen, France. ^[9] UNICANCER, Comprehensive Cancer Center Francois Baclesse, Department of Biopathology, Caen, France. ^[10] Université de Caen Normandie, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France. l.poulain@baclesse.unicancer.fr. ^[11] Université de Caen Normandie, Services Unit PLATON, ORGAPRED Core Facility, Caen, France. l.poulain@baclesse.unicancer.fr. ^[12] UNICANCER, Comprehensive Cancer Center Francois Baclesse, Biological Resources Center 'OvaRessources', Caen, France. l.poulain@baclesse.unicancer.fr. ^[13] Université de Caen Normandie, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France. lb.weiswald@baclesse.unicancer.fr. ^[14] Université de Caen Normandie, Services Unit PLATON, ORGAPRED Core Facility, Caen, France. lb.weiswald@baclesse.unicancer.fr. ^[15] UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France. lb.weiswald@baclesse.unicancer.fr. ^[16]

关键词 Ovarian clear cell carcinoma Patient-derived cell lines Patient-derived tumor organoids Patient-derived xenograft Precision medicine Predictive functional assays

主题词人类(Humans);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);细胞系, 肿瘤(Cell Line, Tumor);治疗结果(Treatment Outcome);类器官(Organoids);癌(Carcinoma)

DOI 10.1186/s13046-023-02809-8

PMID 37803448

发布时间 2023-11-23

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