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A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

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第一作者： Stephen,Boulton

第一单位： Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.

作者： Stephen,Boulton ^[1] ; Joanna,Poutou ^[1] ; Rida,Gill ^[2] ; Nouf,Alluqmani ^[1] ; Xiaohong,He ^[2] ; Ragunath,Singaravelu ^[1] ; Mathieu J F,Crupi ^[1] ; Julia,Petryk ^[2] ; Bradley,Austin ^[2] ; Leonard,Angka ^[2] ; Zaid,Taha ^[1] ; Iris,Teo ^[3] ; Siddarth,Singh ^[2] ; Rameen,Jamil ^[2] ; Ricardo,Marius ^[1] ; Nikolas,Martin ^[2] ; Taylor,Jamieson ^[1] ; Taha,Azad ^[4] ; Jean-Simon,Diallo ^[1] ; Carolina S,Ilkow ^[1] ; John C,Bell ^[1]

作者单位： Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[1] Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada. ^[2] Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.;Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. ^[3] Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.;Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.;Faculty of Medicine and Health Sciences, Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.;Centre de Recherche du CHUS, Sherbrooke, QC J1H 5N4, Canada. ^[4]

关键词 COVID-19 SARS-CoV-2 nucleocapsid poly-epitope spike t cell vaccine vaccinia virus

DOI 10.1016/j.omtm.2023.101110

PMID 37822719

发布时间 2023-10-18

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Molecular therapy. Methods & clinical development

2023年31卷

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Molecular therapy. Methods & clinical development

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A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

Molecular therapy. Methods & clinical development

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A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection.

Molecular therapy. Methods & clinical development

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Molecular therapy. Methods & clinical development

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