Perfluorooctanoic acid disrupts thyroid-specific genes expression and regulation via the TSH-TSHR signaling pathway in thyroid cells.

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作者： Yatao,Du ^[1] ; Chaojie,Chen ^[2] ; Guangdi,Zhou ^[1] ; Zhenzhen,Cai ^[3] ; Qiuhong,Man ^[4] ; Baolin,Liu ^[5] ; Weiye Charles,Wang ^[6]

作者单位： Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200292, China. ^[1] Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China; The Base of Achievement Transformation, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, 200438, China. ^[2] Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200292, China; Department of Clinical Laboratory, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. ^[3] Department of Clinical Laboratory, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. Electronic address: manqiuhong307@163.com. ^[4] Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, 200093, China; Shanghai Co-innovation Center for Energy Therapy of Tumors, Shanghai, 200093, China. Electronic address: blliuk@163.com. ^[5] Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200292, China. Electronic address: wangweiye@xinhuamed.com.cn. ^[6]

关键词 ER stress Glycosylation Hypothyroidism Perfluorooctanoic acid TSH receptor