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Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status.

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第一作者： Jirarat,Poohadsuan

第一单位： Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Siriraj Hospital, Bangkoknoi, Bangkok, 10700, Thailand.

作者： Jirarat,Poohadsuan ^[1] ; George A,O'Doherty ^[2] ; Weerapat,Owattanapanich ^[3] ; Smith,Kungwankiattichai ^[3] ; Yon,Rojanasakul ^[4] ; Surapol,Issaragrisil ^[5] ; Sudjit,Luanpitpong ^[6]

作者单位： Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Siriraj Hospital, Bangkoknoi, Bangkok, 10700, Thailand. ^[1] Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. ^[2] Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.;Center of Excellence of Siriraj Adult Acute Myeloid/Lymphoblastic Leukemia, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. ^[3] Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA.;WVU Cancer Institute, West Virginia University, Morgantown, WV, USA. ^[4] Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Siriraj Hospital, Bangkoknoi, Bangkok, 10700, Thailand.;Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. ^[5] Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Siriraj Hospital, Bangkoknoi, Bangkok, 10700, Thailand. suidjit@gmail.com. ^[6]

关键词 Acute myeloid leukemia Apoptosis Cardiac glycosides Cell cycle Leukemic stem cell Mcl-1 Ouabain c-Myc