首页> Bioorganic chemistry> Synthesis, characterization, in vitro antimycobacterial and cytotoxicity evaluation, DFT calculations, molecular docking and ADME studies of new isomeric benzimidazole-1,2,3-triazole-quinoline hybrid mixtures.

Synthesis, characterization, in vitro antimycobacterial and cytotoxicity evaluation, DFT calculations, molecular docking and ADME studies of new isomeric benzimidazole-1,2,3-triazole-quinoline hybrid mixtures.

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第一作者： Nombulelo T P,Nyoni

第一单位： School of Chemistry and Physics, College of Agriculture, Engineering and Science, University of KwaZulu Natal, Westville Campus, Durban 4000, South Africa.

作者： Nombulelo T P,Nyoni ^[1] ; Nomagugu B,Ncube ^[1] ; Mbali X,Kubheka ^[2] ; Nompumelelo P,Mkhwanazi ^[2] ; Sibusiso,Senzani ^[3] ; Thishana,Singh ^[1] ; Matshawandile,Tukulula ^[4]

作者单位： School of Chemistry and Physics, College of Agriculture, Engineering and Science, University of KwaZulu Natal, Westville Campus, Durban 4000, South Africa. ^[1] HIV Pathogenesis Programme, Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, College of Heath Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. ^[2] School of Laboratory Medicine and Medical Science, College of Heath Health Sciences, University of KwaZulu Natal, Medical School Campus, Durban 4001, South Africa. ^[3] School of Chemistry and Physics, College of Agriculture, Engineering and Science, University of KwaZulu Natal, Westville Campus, Durban 4000, South Africa. Electronic address: TukululaM@ukzn.ac.za. ^[4]

关键词 2,3-Triazole-quinoline hybrids Antitubercular activity Benzimidazole-1 Cytotoxicity Density functional theory (DFT) studies In silico ADME Molecular docking