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MSI-XGNN: an explainable GNN computational framework integrating transcription- and methylation-level biomarkers for microsatellite instability detection.

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第一作者： Yang,Cao

第一单位： Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China.

作者： Yang,Cao ^[1] ; Dan,Wang ^[2] ; Jin,Wu ^[3] ; Zhanxin,Yao ^[3] ; Si,Shen ^[4] ; Chao,Niu ^[1] ; Ying,Liu ^[1] ; Pengcheng,Zhang ^[1] ; Quannian,Wang ^[5] ; Jinhao,Wang ^[1] ; Hua,Li ^[6] ; Xi,Wei ^[6] ; Xinxing,Wang ^[1] ; Qingyang,Dong ^[1]

作者单位： Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China. ^[1] Department of Bioinformatics, Yicon (Beijing) Biomedical Technology Inc. ^[2] Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China. ^[3] School and Hospital of Stomatology, Tianjin Medical University, Tianjin 300050, China. ^[4] School of Basic Medicine, Jiamusi University. ^[5] Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. ^[6]

关键词 DNA methylation MSI markers MSI prediction explainable graph neural network gene expression microsatellite instability