首页> Frontiers in molecular biosciences> AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of <i>de novo</i> humanized and sequence-optimized single domain antibodies: a prospective case study.

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of <i>de novo</i> humanized and sequence-optimized single domain antibodies: a prospective case study.

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第一作者： Paul,Arras

第一单位： Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.;Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.

作者： Paul,Arras ^[1] ; Han Byul,Yoo ^[2] ; Lukas,Pekar ^[2] ; Thomas,Clarke ^[3] ; Lukas,Friedrich ^[4] ; Christian,Schröter ^[5] ; Jennifer,Schanz ^[5] ; Jason,Tonillo ^[5] ; Vanessa,Siegmund ^[6] ; Achim,Doerner ^[2] ; Simon,Krah ^[2] ; Enrico,Guarnera ^[2] ; Stefan,Zielonka ^[1] ; Andreas,Evers ^[2]

作者单位： Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.;Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany. ^[1] Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany. ^[2] Bioinformatics, EMD Serono, Billerica, MA, United States. ^[3] Computational Chemistry and Biologics, Merck Healthcare KGaA, Darmstadt, Germany. ^[4] ADCs & Targeted NBE Therapeutics, Merck KGaA, Darmstadt, Germany. ^[5] Early Protein Supply and Characterization, Merck Healthcare KGaA, Darmstadt, Germany. ^[6]

关键词 artificial intelligence and machine learning (ML)deep learning in silico developability long short-term memory (LSTM)next-generation sequencing (NGS)protein engineering single domain antibodies (VHH)yeast surface display (YSD)

DOI 10.3389/fmolb.2023.1249247

PMID 37842638

发布时间 2024-09-26

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Frontiers in molecular biosciences

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Frontiers in molecular biosciences

2023年10卷

1249247页

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AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of <i>de novo</i> humanized and sequence-optimized single domain antibodies: a prospective case study.

Frontiers in molecular biosciences

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Frontiers in molecular biosciences

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AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of <i>de novo</i> humanized and sequence-optimized single domain antibodies: a prospective case study.

Frontiers in molecular biosciences

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Frontiers in molecular biosciences

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