The 8-bromobaicalein alleviated chikungunya-induced musculoskeletal inflammation and reduced the viral load in healthy adult mice.

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作者： Van,Cao ^[1] ; Naphat,Loeanurit ^[2] ; Kowit,Hengphasatporn ^[3] ; Rita,Hairani ^[1] ; Noppadol,Wacharachaisurapol ^[4] ; Nantaporn,Prompila ^[5] ; Supeecha,Wittayalertpanya ^[6] ; Yasuteru,Shigeta ^[7] ; Tanatorn,Khotavivattana ^[6] ; Warinthorn,Chavasiri ^[7] ; Siwaporn,Boonyasuppayakorn ^[4]

作者单位： Center of Excellence in Applied Medical Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ^[1] Interdisciplinary Program in Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand. ^[2] DaNang University of Medical Technology and Pharmacy, DaNang, Vietnam. ^[3] Center for Computational Sciences, University of Tsukuba, Tsukuba, Japan. ^[4] Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. ^[5] Clinical Pharmakokinetics and Pharmacogenomics Research Unit, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ^[6] Chula Pharmacokinetic Research Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ^[7] Center of Excellence in Vaccine Research and Development, Chulalongkorn University (Chula-VRC), Bangkok, Thailand. ^[8]

关键词 8-bromobaicalein Drug discovery chikungunya virus flavone derivatives flavonoid in vivo efficacy