Engineering of cytosine base editors with DNA damage minimization and editing scope diversification.

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第一作者： Bo,Yuan

第一单位： Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.

作者： Bo,Yuan ^[1] ; Shuqian,Zhang ^[2] ; Liting,Song ^[1] ; Jinlong,Chen ^[3] ; Jixin,Cao ^[4] ; Jiayi,Qiu ^[5] ; Zilong,Qiu ^[1] ; Jingqi,Chen ^[4] ; Xing-Ming,Zhao ^[1] ; Tian-Lin,Cheng ^[2]

作者单位： Institute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China. ^[1] Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. ^[2] Department of Pediatrics, Qilu Hospital of Shandong University, Ji'nan 250012, China. ^[3] Institute of Science and Technology for Brain-inspired Intelligence, Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China. ^[4] National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. ^[5] Songjiang Hospital, Songjiang Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[6] State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China. ^[7] MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. ^[8]

主题词人类(Humans);胞嘧啶(Cytosine);RNA(RNA);DNA损伤(DNA Damage);DNA(DNA)

DOI 10.1093/nar/gkad855

PMID 37843111

发布时间 2023-11-16

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准确一般字义偏差语意偏离译文作用小提交