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Membrane remodeling properties of the Parkinson's disease protein LRRK2.

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第一作者： Xinbo,Wang

第一单位： Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.;Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.;HHMI, Yale University School of Medicine, New Haven, CT 06510.;Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510.;Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.

作者： Xinbo,Wang ^[1] ; Javier,Espadas ^[2] ; Yumei,Wu ^[1] ; Shujun,Cai ^[1] ; Jinghua,Ge ^[3] ; Lin,Shao ^[4] ; Aurélien,Roux ^[2] ; Pietro,De Camilli ^[5]

作者单位： Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.;Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.;HHMI, Yale University School of Medicine, New Haven, CT 06510.;Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510.;Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815. ^[1] Department of Biochemistry, University of Geneva, Geneva CH-1211, Switzerland. ^[2] Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510. ^[3] Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.;Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510. ^[4] Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.;Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.;HHMI, Yale University School of Medicine, New Haven, CT 06510.;Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510.;Aligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.;Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510. ^[5]

关键词 GTPase LRRK2 Parkinson membrane curvature tubulation

医学主题词人类(Humans);帕金森病(Parkinson Disease);磷酰化(Phosphorylation);突变(Mutation)

DOI 10.1073/pnas.2309698120

PMID 37844218

发布时间 2025-09-30

基金项目

P30 DA018343/DA/NIDA NIH HHS/United States

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