首页> EMBO reports> The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.

The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.

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第一作者： Busra,Turgu

第一单位： Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.;Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

作者： Busra,Turgu ^[1] ; Amal,El-Naggar ^[2] ; Melanie,Kogler ^[3] ; Luigi,Tortola ^[4] ; Hai-Feng,Zhang ^[5] ; Mariam,Hassan ^[5] ; Michael M,Lizardo ^[5] ; Sonia Hy,Kung ^[6] ; Wan,Lam ^[7] ; Josef M,Penninger ^[8] ; Poul H,Sorensen ^[7]

作者单位： Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.;Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. ^[1] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.;Department of Pathology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt. ^[2] Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria. ^[3] Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.;Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland. ^[4] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada. ^[5] Department of Urological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada. ^[6] Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.;Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. ^[7] Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.;Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.;Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.;Helmholtz Centre for Infection Research, Braunschweig, Germany. ^[8]

关键词 E3 ubiquitin ligase HACE1 RAC1 mTORC1 and mTORC2 tumor suppressor gene

医学主题词动物(Animals);小鼠(Mice);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);泛素(Ubiquitin);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.15252/embr.202356815

PMID 37846480

发布时间 2025-11-18

基金项目

PBEZP3_145993/SNSF_/Swiss National Science Foundation/Switzerland

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