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Examination of the Rate and Extent of Drug Released from Commercial Topical Delivery Systems During Wear: An Example with Lidocaine Topical Systems.

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第一作者： Qing,Cai

第一单位： Lachman Institute for Pharmaceutical Analysis, Long Island University, Brooklyn, NY, USA.;Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA.

作者： Qing,Cai ^[1] ; Armita,Azarpanah ^[2] ; Jayshil A,Bhatt ^[1] ; Hui,Wei ^[1] ; Jamie,Carr ^[3] ; Kenneth R,Morris ^[1] ; Caroline,Strasinger ^[4] ; Nicole K,Brogden ^[5]

作者单位： Lachman Institute for Pharmaceutical Analysis, Long Island University, Brooklyn, NY, USA.;Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA. ^[1] Lachman Institute for Pharmaceutical Analysis, Long Island University, Brooklyn, NY, USA.;Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA.;Samuel J. and Joan B. Williamson Institute for Pharmacometrics, Long Island University, Brooklyn, NY, USA. ^[2] Institute for Clinical and Translational Sciences, University of Iowa, Hospitals and Clinics, Iowa City, IA, USA. ^[3] United States Food and Drug Administration, CDER, Office of Pharmaceutical Quality, Silver Spring, MD, USA. ^[4] Department of Pharmaceutical Sciences and Experimental Therapeutics, University of Iowa College of Pharmacy, 180 South Grand Avenue, 552 CPB, Iowa City, IA, 52242-1112, USA. nicole-brogden@uiowa.edu.;Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. nicole-brogden@uiowa.edu. ^[5]

关键词 lidocaine pharmacokinetics release topical delivery systems

医学主题词人类(Humans);利多卡因(Lidocaine);药用制剂(Pharmaceutical Preparations);色谱法, 液相(Chromatography, Liquid);串联质谱法(Tandem Mass Spectrometry);投药, 皮肤(Administration, Cutaneous);药物释放系统(Drug Delivery Systems)

DOI 10.1007/s11095-023-03617-7

PMID 37848751

发布时间 2024-02-06

基金项目

5U01FD004275/National Institute for Pharmaceutical Technology and Education CTSA U54R001356/The National Institutes of Health

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