High efficacy of particle beam therapies against tumors under hypoxia and prediction of the early stage treatment effect using 3'-deoxy-3'-[<sup>18</sup>F]fluorothymidine positron emission tomography.

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作者： Akira,Makino ^[1] ; Kyo,Kume ^[2] ; Tetsuya,Mori ^[3] ; Tetsuya,Tsujikawa ^[3] ; Tatsuya,Asai ^[4] ; Hidehiko,Okazawa ^[5] ; Yasushi,Kiyono ^[6]

作者单位： Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui, 910-1193, Japan. amakino@u-fukui.ac.jp.;Life Science Innovation Center, University of Fukui, 9-1 Bunkyo-3, Fukui-Shi, Fukui, 910-8507, Japan. amakino@u-fukui.ac.jp. ^[1] The Wakasa Wan Energy Research Center, 64-52-1 Nagatani, Tsuruga-Shi, Fukui, 914-0192, Japan. ^[2] Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui, 910-1193, Japan. ^[3] Graduate School of Engineering, University of Fukui, 9-1 Bunkyo-3, Fukui-Shi, Fukui, 910-8507, Japan. ^[4] Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui, 910-1193, Japan.;Life Science Innovation Center, University of Fukui, 9-1 Bunkyo-3, Fukui-Shi, Fukui, 910-8507, Japan. ^[5] Biomedical Imaging Research Center, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-Cho, Yoshida-Gun, Fukui, 910-1193, Japan. ykiyono@u-fukui.ac.jp.;Life Science Innovation Center, University of Fukui, 9-1 Bunkyo-3, Fukui-Shi, Fukui, 910-8507, Japan. ykiyono@u-fukui.ac.jp. ^[6]

关键词 3'-Deoxy-3'-[18F]fluorothymidine (18F-FLT)Hypoxia Particle beam therapy Positron emission tomography

主题词人类(Humans);小鼠(Mice);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);正电子发射断层显像术(Positron-Emission Tomography);碳(Carbon);双脱氧核苷类(Dideoxynucleosides)

DOI 10.1007/s12149-023-01877-2

PMID 37856073

发布时间 2024-10-23

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