Amitriptyline at Low-Dose and Titrated for Irritable Bowel Syndrome as Second-Line Treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial.

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第一作者： Alexander C,Ford

第一单位： Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK. Electronic address: A.C.Ford@leeds.ac.uk.

作者： Alexander C,Ford ^[1] ; Alexandra,Wright-Hughes ^[2] ; Sarah L,Alderson ^[2] ; Pei-Loo,Ow ^[2] ; Matthew J,Ridd ^[3] ; Robbie,Foy ^[4] ; Gina,Bianco ^[2] ; Felicity L,Bishop ^[5] ; Matthew,Chaddock ^[6] ; Heather,Cook ^[2] ; Deborah,Cooper ^[4] ; Catherine,Fernandez ^[2] ; Elspeth A,Guthrie ^[4] ; Suzanne,Hartley ^[2] ; Amy,Herbert ^[3] ; Daniel,Howdon ^[4] ; Delia P,Muir ^[2] ; Taposhi,Nath ^[2] ; Sonia,Newman ^[7] ; Thomas,Smith ^[2] ; Christopher A,Taylor ^[2] ; Emma J,Teasdale ^[5] ; Ruth,Thornton ^[7] ; Amanda J,Farrin ^[2] ; Hazel A,Everitt ^[7] ; ATLANTIS trialists

作者单位： Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK. Electronic address: A.C.Ford@leeds.ac.uk. ^[1] Clinical Trial Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. ^[2] Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. ^[3] Leeds Institute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK. ^[4] Centre for Clinical and Community Applications of Health Psychology, School of Psychology, University of Southampton, Southampton, UK. ^[5] Let'sCure IBS, Leeds, UK. ^[6] Primary Care Research Centre, Faculty of Medicine, University of Southampton, Southampton, UK. ^[7]