Formation and clearance of TNF-TNF inhibitor complexes during TNF inhibitor treatment.

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第一作者： Lea Catharina,Berkhout

第一单位： Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.;Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

作者： Lea Catharina,Berkhout ^[1] ; Merel Jeanne,I'Ami ^[2] ; Simone,Kruithof ^[3] ; Erik Hans,Vogelzang ^[1] ; Femke,Hooijberg ^[2] ; Margaretha Hendrika Louise,Hart ^[3] ; Arthur Ebel Herman,Bentlage ^[2] ; Debby,Thomas ^[3] ; Severine,Vermeire ^[1] ; Gestur,Vidarsson ^[4] ; Anja,Ten Brinke ^[5] ; Michael Twahier,Nurmohamed ^[6] ; Gerrit Jan,Wolbink ^[4] ; Theo,Rispens ^[1]

作者单位： Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.;Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. ^[1] Amsterdam Rheumatology and Immunology Center ^[2] Reade, Amsterdam, The Netherlands. ^[3] Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.;Department of Experimental Immunohematology, Sanquin Research, Amsterdam, The Netherlands. ^[4] Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, Katholieke Universiteit Leuven, Leuven, Belgium. ^[5] Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.;Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.;Translational Research in Gastrointestinal Disorders, University Hospitals Leuven, Leuven, Belgium. ^[6] Reade, Amsterdam, The Netherlands.;Amsterdam Rheumatology and Immunology Center ^[7] VU University Medical Center, Amsterdam, The Netherlands. ^[8] Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.;Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.;Amsterdam Rheumatology and Immunology Center ^[9]

关键词 TNF inhibitor anti-drug antibodies clearance immune complexes pharmacokinetic target-mediated drug disposition tumour necrosis factor

主题词人类(Humans);抗风湿药(Antirheumatic Agents);关节炎, 类风湿(Arthritis, Rheumatoid);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1111/bph.16269

PMID 37859583

发布时间 2024-03-19

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