Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.

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作者： Min Jae,Jeon ^[1] ; Hyelim,Lee ^[2] ; Seongman,Jo ^[3] ; Miso,Kang ^[4] ; Jeong Hyun,Jeong ^[2] ; So Hyeon,Jeong ^[3] ; Joo-Youn,Lee ^[1] ; Gyu Yong,Song ^[5] ; Hyunah,Choo ^[2] ; Sanghee,Lee ^[6] ; Hyejin,Kim ^[7]

作者单位： Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. ^[1] Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea. ^[2] Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea; Department of Pharmacy, College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. ^[3] Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; Department of Basic Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, 02447, Republic of Korea. ^[4] Department of Pharmacy, College of Pharmacy, Chungnam National University, Daejeon, 34134, Republic of Korea. ^[5] Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea; Department for HY-KIST Bio-convergence, Hanyang University, Seoul, 04763, Republic of Korea. Electronic address: slee19@kist.re.kr. ^[6] Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea. Electronic address: hjinkim@krict.re.kr. ^[7]

关键词 Anti-cancer therapy Immunomodulatory agent Monomeric amidobenzimidazole Oral administration STING agonist Stimulator of interferon genes

主题词小鼠(Mice);动物(Animals);免疫, 先天(Immunity, Innate);免疫疗法(Immunotherapy);干扰素类(Interferons);肿瘤(Neoplasms)

DOI 10.1016/j.ejmech.2023.115834

PMID 37862818

发布时间 2023-11-03

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