Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

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第一作者： Xiaodi,Yu

第一单位： Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, PA, 19477, USA. xyu6@its.jnj.com.

作者： Xiaodi,Yu ^[1] ; Pravien,Abeywickrema ^[2] ; Brecht,Bonneux ^[3] ; Ishani,Behera ^[4] ; Brandon,Anson ^[5] ; Edgar,Jacoby ^[5] ; Amy,Fung ^[6] ; Suraj,Adhikary ^[5] ; Anusarka,Bhaumik ^[2] ; Rodrigo J,Carbajo ^[2] ; Suzanne,De Bruyn ^[7] ; Robyn,Miller ^[3] ; Aaron,Patrick ^[2] ; Quyen,Pham ^[2] ; Madison,Piassek ^[5] ; Nick,Verheyen ^[2] ; Afzaal,Shareef ^[3] ; Priscila,Sutto-Ortiz ^[8] ; Nina,Ysebaert ^[9] ; Herman,Van Vlijmen ^[3] ; Tim H M,Jonckers ^[6] ; Florence,Herschke ^[6] ; Jason S,McLellan ^[3] ; Etienne,Decroly ^[10] ; Rachel,Fearns ^[9] ; Sandrine,Grosse ^[8] ; Dirk,Roymans ^[6] ; Sujata,Sharma ^[3] ; Peter,Rigaux ^[2] ; Zhinan,Jin ^[3]

作者单位： Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, PA, 19477, USA. xyu6@its.jnj.com. ^[1] Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, PA, 19477, USA. ^[2] Janssen Infectious Diseases and Vaccines, 2340, Beerse, Belgium. ^[3] University of Antwerp, Antwerp, Belgium. ^[4] Johnson & Johnson Innovative Medicine, Brisbane, CA, 94005, USA. ^[5] Johnson & Johnson Innovative Medicine, Beerse, Belgium. ^[6] Johnson & Johnson Innovative Medicine, Janssen-Cilag, Discovery Chemistry S.A. Río Jarama, 75A, 45007, Toledo, Spain. ^[7] Department of Microbiology, National Emerging Infectious Diseases Laboratories, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA. ^[8] Aix Marseille Université, CNRS, AFMB, UMR 7257, Marseille, France. ^[9] Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, 78712, USA. ^[10] Johnson & Johnson Innovative Medicine, Brisbane, CA, 94005, USA. zjin14@its.jnj.com. ^[11]

主题词呼吸道合胞体病毒, 人(Respiratory Syncytial Virus, Human);蛋白质结合(Protein Binding);RNA(RNA);核苷酸类(Nucleotides)

DOI 10.1038/s42003-023-05451-4

PMID 37865687

发布时间 2023-11-18

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Communications biology

2023年6卷1期

1074页

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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

Communications biology

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Communications biology

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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.

Communications biology

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Communications biology

相关期刊

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