Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC.

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作者： Fei,Xu ^[1] ; Tongtong,Zang ^[2] ; Han,Chen ^[2] ; Changyi,Zhou ^[2] ; Rui,Wang ^[2] ; Yue,Yu ^[2] ; Li,Shen ^[3] ; Juying,Qian ^[4] ; Junbo,Ge ^[5]

作者单位： Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine & Shanghai Clinical Research Center for Interventional Medicine (19MC1910300), Shanghai, China; Department of Cardiology and Laboratory of Heart Valve Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ^[1] Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine & Shanghai Clinical Research Center for Interventional Medicine (19MC1910300), Shanghai, China. ^[2] Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine & Shanghai Clinical Research Center for Interventional Medicine (19MC1910300), Shanghai, China. Electronic address: shen.li1@zs-hospital.sh.cn. ^[3] Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine & Shanghai Clinical Research Center for Interventional Medicine (19MC1910300), Shanghai, China. Electronic address: qian.juying@zs-hospital.sh.cn. ^[4] Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Institute of Cardiovascular Diseases, Shanghai, China; National Clinical Research Center for Interventional Medicine & Shanghai Clinical Research Center for Interventional Medicine (19MC1910300), Shanghai, China. Electronic address: ge.junbo2@zs-hospital.sh.cn. ^[5]

关键词 Cardiotoxicity Deubiquitinase Doxorubicin Heart failure OTUB1

主题词小鼠(Mice);动物(Animals);多柔比星(Doxorubicin);肌细胞, 心脏(Myocytes, Cardiac);氧化性应激(Oxidative Stress);细胞凋亡(Apoptosis);抗氧化剂(Antioxidants)

DOI 10.1016/j.cellsig.2023.110937

PMID 37871668

发布时间 2024-03-22

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