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Transcription factor stoichiometry, motif affinity and syntax regulate single-cell chromatin dynamics during fibroblast reprogramming to pluripotency.

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第一作者： Surag,Nair

第一单位： Department of Computer Science, Stanford University, Stanford, CA, USA.

作者： Surag,Nair ^[1] ; Mohamed,Ameen ^[2] ; Laksshman,Sundaram ^[1] ; Anusri,Pampari ^[1] ; Jacob,Schreiber ^[3] ; Akshay,Balsubramani ^[3] ; Yu Xin,Wang ^[4] ; David,Burns ^[4] ; Helen M,Blau ^[5] ; Ioannis,Karakikes ^[6] ; Kevin C,Wang ^[7] ; Anshul,Kundaje ^[8]

作者单位： Department of Computer Science, Stanford University, Stanford, CA, USA. ^[1] Department of Cancer Biology, Stanford University, Stanford, CA, USA.;Cardiovascular Institute, Stanford University, Stanford, CA, USA.;Department of Dermatology, Stanford University, Stanford, CA, USA.;Program in Epithelial Biology, Stanford University, Stanford, CA, USA. ^[2] Department of Genetics, Stanford University, Stanford, CA, USA. ^[3] Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA, USA. ^[4] Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, CA, USA.;Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA. ^[5] Cardiovascular Institute, Stanford University, Stanford, CA, USA.;Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA. ^[6] Department of Dermatology, Stanford University, Stanford, CA, USA.;Program in Epithelial Biology, Stanford University, Stanford, CA, USA.;Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA. ^[7] Department of Computer Science, Stanford University, Stanford, CA, USA.;Department of Genetics, Stanford University, Stanford, CA, USA. ^[8]

DOI 10.1101/2023.10.04.560808

PMID 37873116

发布时间 2024-10-01

基金项目

R01 GM136737/GM/NIGMS NIH HHS/United States R01 HG009674/HG/NHGRI NIH HHS/United States R61 AR076815/AR/NIAMS NIH HHS/United States

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Transcription factor stoichiometry, motif affinity and syntax regulate single-cell chromatin dynamics during fibroblast reprogramming to pluripotency.

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Transcription factor stoichiometry, motif affinity and syntax regulate single-cell chromatin dynamics during fibroblast reprogramming to pluripotency.

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