Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes.

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作者： Wei-Xin,Chin ^[1] ; Hao Yuin,Kong ^[2] ; Isabelle Xin Yu,Zhu ^[1] ; Zi Yun,Teo ^[1] ; Regina,Faruk ^[1] ; Regina Ching Hua,Lee ^[1] ; Si Xian,Ho ^[1] ; Zhen Qin,Aw ^[2] ; Bowen,Yi ^[2] ; Xin Jun,Hou ^[3] ; Antson Kiat Yee,Tan ^[4] ; Thinesshwary,Yogarajah ^[5] ; Roland G,Huber ^[1] ; Yu,Cai ^[6] ; Yue,Wan ^[3] ; Justin Jang Hann,Chu ^[4]

作者单位： Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology and Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore. ^[1] NUSMed Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[2] Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore. ^[3] Department of Biological Sciences, National University of Singapore, Singapore. ^[4] Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore. ^[5] Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore. ^[6] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore. ^[7]