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A robust pipeline for high-content, high-throughput immunophenotyping reveals age- and genetics-dependent changes in blood leukocytes.

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第一作者： Thomas,Liechti

第一单位： ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA. Electronic address: liechti.thom@gmail.com.

作者： Thomas,Liechti ^[1] ; Sofie,Van Gassen ^[2] ; Margaret,Beddall ^[3] ; Reid,Ballard ^[3] ; Yaser,Iftikhar ^[3] ; Renguang,Du ^[3] ; Thiagarajan,Venkataraman ^[4] ; David,Novak ^[2] ; Massimo,Mangino ^[5] ; Stephen,Perfetto ^[3] ; H Benjamin,Larman ^[4] ; Tim,Spector ^[6] ; Yvan,Saeys ^[2] ; Mario,Roederer ^[7]

作者单位： ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA. Electronic address: liechti.thom@gmail.com. ^[1] Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium. ^[2] ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA. ^[3] Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. ^[4] Department of Twin Research & Genetic Epidemiology, King's College London, London, UK; National Heart and Lung Institute, Cardiovascular Science Division, Imperial College London, London, UK. ^[5] Department of Twin Research & Genetic Epidemiology, King's College London, London, UK. ^[6] ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA. Electronic address: marior@mail.nih.gov. ^[7]

关键词 CP: Immunology CP: Systems biology flow cytometry high-dimensional flow cytometry human immunology immune aging immune homeostasis immune regulation immunophenotyping studies large cohorts

医学主题词人类(Humans);免疫表型分型(Immunophenotyping);结果可重复性(Reproducibility of Results);白细胞(Leukocytes);流式细胞术(Flow Cytometry);B淋巴细胞亚群(B-Lymphocyte Subsets)

DOI 10.1016/j.crmeth.2023.100619

PMID 37883924

发布时间 2024-09-19

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