Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen.

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第一作者： Maximilian,Schmutz

第一单位： Hematology and Oncology, Medical Faculty, University of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.

作者： Maximilian,Schmutz ^[1] ; Manuela,Zucknick ^[2] ; Richard F,Schlenk ^[2] ; Daniel,Mertens ^[3] ; Axel,Benner ^[4] ; Dieter,Weichenhan ^[5] ; Oliver,Mücke ^[6] ; Konstanze,Döhner ^[7] ; Christoph,Plass ^[8] ; Lars,Bullinger ^[2] ; Rainer,Claus ^[2]

作者单位： Hematology and Oncology, Medical Faculty, University of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany. ^[1] Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[2] Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway. ^[3] NCT-Trial Center, National Center of Tumor Diseases, German Cancer Research Center, Heidelberg University Hospital, Heidelberg, Germany. ^[4] Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. ^[5] Cooperation Unit "Mechanisms of Leukemogenesis", German Cancer Research Center, Heidelberg, Germany. ^[6] Division of Chronic Lymphocytic Leukemia, Department of Internal Medicine III, Ulm University Medical Center, Ulm, Germany. ^[7] Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[8] Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany. ^[9] German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany. ^[10] Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow Klinikum, Berlin, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. ^[11] Hematology and Oncology, Medical Faculty, University of Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany. rainer.claus@uk-augsburg.de. ^[12] Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. rainer.claus@uk-augsburg.de. ^[13] Pathology, Medical Faculty, University of Augsburg, Augsburg, Germany. rainer.claus@uk-augsburg.de. ^[14]

关键词 AML Azacytidine DNA methylation patterns DNA-methylation Epigenetics HMA-treatment Predictive biomarker Predictive signature

主题词人类(Humans);阿扎胞苷(Azacitidine);骨髓(Bone Marrow);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);白血病, 髓样, 急性(Leukemia, Myeloid, Acute)

DOI 10.1186/s13148-023-01580-z

PMID 37885041

发布时间 2023-11-06

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