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Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids.

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第一作者： Jinlun,Bai

第一单位： The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Development, Stem Cell, and Regenerative Medicine Program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

作者： Jinlun,Bai ^[1] ; David S,Koos ^[2] ; Kayla,Stepanian ^[3] ; Zachary,Fouladian ^[1] ; Dominic W H,Shayler ^[1] ; Jennifer G,Aparicio ^[3] ; Scott E,Fraser ^[4] ; Rex A,Moats ^[5] ; David,Cobrinik ^[6]

作者单位： The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Development, Stem Cell, and Regenerative Medicine Program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. ^[1] The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Translational Biomedical Imaging Laboratory, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. ^[2] The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. ^[3] The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Translational Biomedical Imaging Laboratory, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA.;Translational Imaging Center, University of Southern California, Los Angeles, CA 90089, USA. ^[4] The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Translational Biomedical Imaging Laboratory, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA. ^[5] The Vision Center, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.;Department of Ophthalmology and Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.;Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.;Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. ^[6]

关键词 CRISPR Cone photoreceptor Fluorescent reporter GNAT2 Live imaging Retinal organoid iPSC

医学主题词人类(Humans);视锥光感受器细胞(Retinal Cone Photoreceptor Cells);诱导多能干细胞(Induced Pluripotent Stem Cells);视网膜(Retina);类器官(Organoids);细胞分化(Cell Differentiation)

DOI 10.1242/dmm.050193

PMID 37902188

发布时间 2025-08-15

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