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Electrophysiological characterisation of iPSC-derived human β-like cells and an <i>SLC30A8</i> disease model.

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第一作者： Manon,Jaffredo

第一单位： University of Bordeaux, CNRS, Institute of Chemistry and Biology of Membranes and Nano-objects, UMR 5248, Pessac, France.

作者： Manon,Jaffredo ^[1] ; Nicole A J,Krentz ^[2] ; Benoite,Champon ^[3] ; Claire E,Duff ^[3] ; Sameena,Nawaz ^[4] ; Nicola,Beer ^[4] ; Christian,Honore ^[5] ; Anne,Clark ^[4] ; Patrik,Rorsman ^[4] ; Jochen,Lang ^[1] ; Anna L,Gloyn ^[6] ; Matthieu,Raoux ^[1] ; Benoit,Hastoy ^[4]

作者单位： University of Bordeaux, CNRS, Institute of Chemistry and Biology of Membranes and Nano-objects, UMR 5248, Pessac, France. ^[1] Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Department of Pediatrics, Stanford School of Medicine, Stanford University, CA, USA. ^[2] Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. ^[3] Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. ^[4] Cell Therapy R&D, Novo Nordisk A/S, 2760 Måløv, Denmark. ^[5] Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.;Department of Pediatrics, Stanford School of Medicine, Stanford University, CA, USA.;Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. ^[6]

关键词 Multielectrode array SLC30A8 electrical activity electrical coupling electrophysiology exocytosis hiPSC-derived Beta-like cells insulin secretion

DOI 10.1101/2023.10.17.561014

PMID 37905040

发布时间 2024-07-22

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Electrophysiological characterisation of iPSC-derived human β-like cells and an <i>SLC30A8</i> disease model.

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Electrophysiological characterisation of iPSC-derived human β-like cells and an <i>SLC30A8</i> disease model.

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