Nanobody-mediated SPECT/CT imaging reveals the spatiotemporal expression of programmed death-ligand 1 in response to a CD8<sup>+</sup> T cell and iNKT cell activating mRNA vaccine.

导出 OA

翻译打印收藏纠错

作者： Thomas,Ertveldt ^[1] ; Sofie,Meulewaeter ^[2] ; Yannick,De Vlaeminck ^[3] ; Oscar,Olarte ^[1] ; Katrijn,Broos ^[4] ; Serge,Van Calenbergh ^[1] ; Stephanie,Bourgeois ^[5] ; Joke,Deprez ^[6] ; Yves,Heremans ^[2] ; Cleo,Goyvaerts ^[3] ; Willem,Staels ^[7] ; Stefaan,De Smedt ^[1] ; Heleen,Dewitte ^[6] ; Nick,Devoogdt ^[8] ; Marleen,Keyaerts ^[2] ; Rein,Verbeke ^[3] ; Kurt,Barbé ^[2] ; Ine,Lentacker ^[3] ; Karine,Breckpot ^[9]

作者单位： Laboratory for Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. ^[1] Ghent research Group on Nanomedicines, Laboratory of Physical Pharmacy and General Biochemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Gent, Belgium. ^[2] Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent University, Ghent B-9000, Belgium. ^[3] Biostatistics and Medical Informatics Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. ^[4] Laboratory of Medicinal Chemistry, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000, Belgium. ^[5] Beta Cell Neogenesis (BENE), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium. ^[6] Visual and Spatial Tissue Analysis (VSTA) Core Facility, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. ^[7] Universitair Ziekenhuis Brussel (UZ Brussel), Department of Pediatrics, Division of Pediatric Endocrinology, Brussels, Belgium. ^[8] Medical Imaging department, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. ^[9] Nuclear Medicine Department, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium. ^[10]

关键词 mRNA vaccine melanoma nanobody programmed death-ligand 1 single-photon emission computerized tomography/computed tomography