换一批
换一批Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
作者：
Andreas,Varkaris [1]
;
Ermira,Pazolli [2]
;
Hakan,Gunaydin [2]
;
Qi,Wang [3]
;
Levi,Pierce [2]
;
Alessandro A,Boezio [2]
;
Artemisa,Bulku [2]
;
Lucian,DiPietro [2]
;
Cary,Fridrich [2]
;
Adam,Frost [4]
;
Fabrizio,Giordanetto [5]
;
Erika P,Hamilton [6]
;
Katherine,Harris [3]
;
Michael,Holliday [7]
;
Tamieka L,Hunter [8]
;
Amanda,Iskandar [2]
;
Yongli,Ji [2]
;
Alexandre,Larivée [2]
;
Jonathan R,LaRochelle [9]
;
André,Lescarbeau [10]
;
Fabien,Llambi [2]
;
Brenda,Lormil [2]
;
Mary M,Mader [2]
;
Brenton G,Mar [1]
;
Iain,Martin [2]
;
Thomas H,McLean [2]
;
Klaus,Michelsen [2]
;
Yakov,Pechersky [2]
;
Erika,Puente-Poushnejad [2]
;
Kevin,Raynor [3]
;
Dipali,Rogala [2]
;
Ramin,Samadani [2]
;
Alison M,Schram [2]
;
Kelley,Shortsleeves [2]
;
Sweta,Swaminathan [11]
;
Shahein,Tajmir [2]
;
Gege,Tan [2]
;
Yong,Tang [12]
;
Roberto,Valverde [2]
;
Bryan,Wehrenberg [2]
;
Jeremy,Wilbur [2]
;
Bret R,Williams [2]
;
Hongtao,Zeng [2]
;
Hanmo,Zhang [2]
;
W Patrick,Walters [2]
;
Beni B,Wolf [2]
;
David E,Shaw [1]
;
Donald A,Bergstrom [2]
;
James,Watters [3]
;
James S,Fraser [13]
;
Pascal D,Fortin [2]
;
D Randal,Kipp [2]
作者单位：
Mass General Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.
[1]
Relay Therapeutics, Inc., Cambridge, Massachusetts.
[2]
D. E. Shaw Research, New York, New York.
[3]
Altos Labs, Institute of Science, San Francisco, California.
[4]
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California.
[5]
California Institute of Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California.
[6]
Sarah Cannon Research Institute/Tennessee Oncology, Nashville, Tennessee.
[7]
MGH/Mass General Cancer Center at Danvers, Danvers, Massachusetts.
[8]
Hematology/Oncology, Exeter Hospital, Exeter, New Hampshire.
[9]
Paraza Pharma, Inc. Montreal, Canada.
[10]
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
[11]
MGH Radiology, Harvard Medical School, Boston, Massachusetts.
[12]
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York.
[13]
Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California.
[14]
主题词
人类(Humans);女(雌)性(Female);冷冻电子显微镜检查(Cryoelectron Microscopy);乳腺肿瘤(Breast Neoplasms);I类磷脂酰肌醇3-激酶类(Class I Phosphatidylinositol 3-Kinases);高胰岛素血症(Hyperinsulinism);DNA(DNA)
DOI
10.1158/2159-8290.CD-23-0944
PMID
37916956
发布时间
2024-03-09
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Cancer discovery
Cancer discovery
240-257页
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