A genetically encoded protein tag for control and quantitative imaging of CAR T cell therapy.

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第一作者： Iris K,Lee

第一单位： Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

作者： Iris K,Lee ^[1] ; Nitika,Sharma ^[2] ; Estela,Noguera-Ortega ^[3] ; Maria,Liousia ^[3] ; Miren L,Baroja ^[4] ; Jean M,Etersque ^[5] ; Jonathan,Pham ^[2] ; Swarbhanu,Sarkar ^[2] ; Beatriz M,Carreno ^[4] ; Gerald P,Linette ^[4] ; Ellen,Puré ^[6] ; Steven M,Albelda ^[7] ; Mark A,Sellmyer ^[8]

作者单位： Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[1] Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[2] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[3] Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[4] Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[5] Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[6] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[7] Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: mark.sellmyer@pennmedicine.upenn.edu. ^[8]

关键词 CAR t?cells PET PROTAC cell therapy chimeric antigen receptor positron emission tomography protein regulation proteolysis-targeting chimeric small molecule targeted protein degradation

主题词人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);T淋巴细胞(T-Lymphocytes);四氢叶酸脱氢酶(Tetrahydrofolate Dehydrogenase);受体, 抗原, T细胞(Receptors, Antigen, T-Cell)

DOI 10.1016/j.ymthe.2023.10.020

PMID 37919903

发布时间 2024-12-07

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