Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry and stability-indicating analytical method of selumetinib.

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作者： Sonam,Mishra ^[1] ; Niraj,Rajput ^[1] ; Tarang,Jadav ^[1] ; Niraj Kumar,Panday ^[1] ; Amit Kumar,Sahu ^[1] ; Pinaki,Sengupta ^[1]

作者单位： Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India. ^[1]

关键词 LC-Q-TOF-MS/MS-based characterization degradation impurities degradation mechanism selumetinib stability-indicating analytical method

主题词串联质谱法(Tandem Mass Spectrometry);色谱法, 高压液相(Chromatography, High Pressure Liquid);药物稳定性(Drug Stability);色谱法, 液相(Chromatography, Liquid);药物污染(Drug Contamination)

DOI 10.1002/bmc.5761

PMID 37920143

发布时间 2023-12-21

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Biomedical chromatography

2024年38卷1期

e5761页

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Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry and stability-indicating analytical method of selumetinib.

Biomedical chromatography

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Biomedical chromatography

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Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry and stability-indicating analytical method of selumetinib.

Biomedical chromatography

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Biomedical chromatography

相关期刊

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