Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

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作者： James F,Read ^[1] ; Michael,Serralha ^[2] ; Jesse D,Armitage ^[2] ; Muhammad Munir,Iqbal ^[2] ; Mark N,Cruickshank ^[3] ; Alka,Saxena ^[4] ; Deborah H,Strickland ^[3] ; Jason,Waithman ^[4] ; Patrick G,Holt ^[2] ; Anthony,Bosco ^[5]

作者单位： Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United States. ^[1] Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia. ^[2] School of Biomedical Sciences, The University of Western Australia, Nedlands, Western Australia, Australia. ^[3] Genomics WA, Joint Initiative of Telethon Kids Institute, Harry Perkins Institute of Medical Research and The University of Western Australia, Nedlands, WA, Australia. ^[4] UWA Centre for Child Health Research, The University of Western Australia, Nedlands, WA, Australia. ^[5] Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ, United States. ^[6]

关键词 cord blood interferon lipopolysaccharide poly(I:C)proinflammatory scRNA-Seq single cell genomics toll-like receptors

主题词婴儿, 新生(Infant, Newborn);人类(Humans);脂多糖类(Lipopolysaccharides);单核细胞(Monocytes);信号传导(Signal Transduction);基因表达调控(Gene Expression Regulation);聚肌胞苷酸(Poly I-C)

DOI 10.3389/fimmu.2023.1275937

PMID 37920467

发布时间 2023-11-06

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