Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.

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第一作者： Xiaoteng,Cui

第一单位： Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, P. R. China.

作者： Xiaoteng,Cui ^[1] ; Jixing,Zhao ^[2] ; Guanzhang,Li ^[1] ; Chao,Yang ^[2] ; Shixue,Yang ^[3] ; Qi,Zhan ^[4] ; Junhu,Zhou ^[5] ; Yunfei,Wang ^[1] ; Menglin,Xiao ^[2] ; Biao,Hong ^[6] ; Kaikai,Yi ^[1] ; Fei,Tong ^[2] ; Yanli,Tan ^[1] ; Hu,Wang ^[2] ; Qixue,Wang ^[7] ; Tao,Jiang ^[8] ; Chuan,Fang ^[1] ; Chunsheng,Kang ^[2]

作者单位： Laboratory of Neuro-oncology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, P. R. China. ^[1] Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, P. R. China. ^[2] Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China. ^[3] Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA), Beijing, P. R. China. ^[4] Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P. R. China. ^[5] Tianjin Key Laboratory of Composite and Functional Materials, School of Material Science and Engineering, Tianjin University, Tianjin, P. R. China. ^[6] Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China. ^[7] Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma, Baoding, Hebei, P. R. China. ^[8] Department of Neuro-Oncology and Neurosurgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China. ^[9] Department of Pathology, Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China. ^[10] Department of Pathology, Hebei University School of Basic Medical Sciences, Baoding, Hebei, P. R. China. ^[11] Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, P. R. China. ^[12] Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, P. R. China. ^[13] Research Unit of Accurate Diagnosis, Treatment, and Translational Medicine of Brain Tumors, Chinese Academy of Medical Sciences, Beijing, P. R. China. ^[14]

关键词 EGFR combinatorial therapeutic strategy energy metabolism glioblastoma

主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);能量代谢(Energy Metabolism);脂肪酸类(Fatty Acids);胶质母细胞瘤(Glioblastoma);连接酶类(Ligases);甲羟戊酸(Mevalonic Acid);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt)

DOI 10.1002/cac2.12502

PMID 37920878

发布时间 2024-03-13

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Cancer communications (London, England)

2023年43卷12期

1326-1353页

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Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.

Cancer communications (London, England)

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Cancer communications (London, England)

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Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.

Cancer communications (London, England)

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Cancer communications (London, England)

相关期刊

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