Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease.

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作者： Preety Sthutika,Swain ^[1] ; Sunita,Panda ^[2] ; Sanghamitra,Pati ^[3] ; Budheswar,Dehury ^[4]

作者单位： Bioinformatics Division, ICMR-Regional Medical Research Centre, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, Odisha, India. ^[1] Mycology Laboratory, ICMR-Regional Medical Research Centre, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, Odisha, India. ^[2] Bioinformatics Division, ICMR-Regional Medical Research Centre, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, Odisha, India. drsanghamitra12@gmail.com. ^[3] Bioinformatics Division, ICMR-Regional Medical Research Centre, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, Odisha, India. budheswar.dehury@gmail.com. ^[4]

关键词 Alzheimer’s disease Nasu-Hakola disease Saturated mutagenesis TREM2

主题词人类(Humans);阿尔茨海默病(Alzheimer Disease);配体(Ligands);突变(Mutation);诱变(Mutagenesis);膜糖蛋白类(Membrane Glycoproteins);受体, 免疫(Receptors, Immunologic)

DOI 10.1007/s00894-023-05770-7

PMID 37924367

发布时间 2023-11-08

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