首页> Nature communications> A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis.

A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis.

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第一作者： Philip N,Newsome

第一单位： National Institute for Health Research, Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. p.n.newsome@bham.ac.uk.;Centre for Liver & Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. p.n.newsome@bham.ac.uk.

作者： Philip N,Newsome ^[1] ; Arun J,Sanyal ^[2] ; Guy,Neff ^[3] ; Jörn M,Schattenberg ^[4] ; Vlad,Ratziu ^[5] ; Judith,Ertle ^[6] ; Jasmin,Link ^[7] ; Alison,Mackie ^[7] ; Corinna,Schoelch ^[7] ; Eric,Lawitz ^[8] ; BI 1467335 NASH Phase IIa trial team

作者单位： National Institute for Health Research, Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. p.n.newsome@bham.ac.uk.;Centre for Liver & Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. p.n.newsome@bham.ac.uk. ^[1] Virginia Commonwealth University, Richmond, VA, USA. ^[2] Covenant Research, Sarasota, FL, USA. ^[3] Metabolic Liver Research Program University Medical Center, Mainz, Germany. ^[4] Sorbonne Université, Institute of Cardiometabolism and Nutrition, Hospital Pitié-Salpêtrière, Paris, France. ^[5] Boehringer Ingelheim, Ingelheim am Rhein, Germany. ^[6] Boehringer Ingelheim, Biberach, Germany. ^[7] Texas Liver Institute, University of Texas Health, San Antonio, TX, USA. ^[8]

医学主题词成年人(Adult);人类(Humans);半胱氨酸天冬氨酸蛋白酶(Caspases);双盲法(Double-Blind Method);治疗结果(Treatment Outcome);胺氧化酶(含铜)(Amine Oxidase (Copper-Containing))

DOI 10.1038/s41467-023-42398-w

PMID 37932258

发布时间 2023-11-28

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