TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.

导出 OA

翻译打印收藏纠错

作者： Caili,Xu ^[1] ; Min,Zhu ^[2] ; Qian,Wang ^[1] ; Jiajun,Cui ^[3] ; Yuping,Huang ^[2] ; Xiting,Huang ^[1] ; Jing,Huang ^[2] ; Junwei,Gai ^[2] ; Guanghui,Li ^[2] ; Peng,Qiao ^[2] ; Xian,Zeng ^[1] ; Dianwen,Ju ^[4] ; Yakun,Wan ^[5] ; Xuyao,Zhang ^[6]

作者单位： Department of Biological Medicines and Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, 201203, China. ^[1] Shanghai Novamab Biopharmaceuticals Co., Ltd., Shanghai, 201318, China. ^[2] Tanwei College, Tsinghua University, Beijing, 100084, China. ^[3] Department of Biological Medicines and Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, 201203, China. dianwenju@fudan.edu.cn. ^[4] Shanghai Novamab Biopharmaceuticals Co., Ltd., Shanghai, 201318, China. ykwan@novamab.com. ^[5] Department of Biological Medicines and Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, 201203, China. xuyaozhang@fudan.edu.cn. ^[6]

关键词 Antitumor effect Mechanisms of action Nanobody-drug conjugate Pancreatic cancer TROP2

主题词人类(Humans);抗原, 表面(Antigens, Surface);细胞系, 肿瘤(Cell Line, Tumor);免疫轭合物(Immunoconjugates);胰腺肿瘤(Pancreatic Neoplasms);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);动物(Animals)

DOI 10.1186/s12951-023-02183-9

PMID 37932752

发布时间 2023-12-13

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交