Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders.

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作者： Yige,Huang ^[1] ; Bangyan,Liu ^[2] ; Subhash C,Sinha ^[1] ; Sadaf,Amin ^[2] ; Li,Gan ^[1]

作者单位： Helen and Robert Appel Alzheimer Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. ^[1] Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA. ^[2] Helen and Robert Appel Alzheimer Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. lig2033@med.cornell.edu. ^[3] Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA. lig2033@med.cornell.edu. ^[4]

关键词 ALS Alzheimer disease Antiviral Cytosolic dsDNA Interferon response Neuroinflammation Parkinson disease STING cGAS

主题词人类(Humans);信号传导(Signal Transduction);核苷酸基转移酶类(Nucleotidyltransferases);DNA(DNA);干扰素Ⅰ型(Interferon Type I);神经系统疾病(Nervous System Diseases)

DOI 10.1186/s13024-023-00672-x

PMID 37941028

发布时间 2024-02-10

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