Recurrent Colorectal Liver Metastases: Upfront Local Treatment versus Neoadjuvant Systemic Therapy Followed by Local Treatment (COLLISION RELAPSE): Study Protocol of a Phase III Prospective Randomized Controlled Trial.

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第一作者： Madelon,Dijkstra

第一单位： Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. m.dijkstra3@amsterdamumc.nl.

作者： Madelon,Dijkstra ^[1] ; Babette I,Kuiper ^[2] ; Hannah H,Schulz ^[3] ; Susan,van der Lei ^[3] ; Robbert S,Puijk ^[3] ; Danielle J W,Vos ^[3] ; Florentine E F,Timmer ^[3] ; Hester J,Scheffer ^[4] ; Tineke E,Buffart ^[5] ; M Petrousjka,van den Tol ^[6] ; Birgit I,Lissenberg-Witte ^[7] ; Rutger-Jan,Swijnenburg ^[2] ; Kathelijn S,Versteeg ^[5] ; Martijn R,Meijerink ^[3] ; COLLISION Trial Group

作者单位： Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. m.dijkstra3@amsterdamumc.nl. ^[1] Department of Surgery, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, Amsterdam, The Netherlands. ^[2] Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. ^[3] Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.;Department of Radiology and Nuclear Medicine, Noordwest Ziekenhuisgroep, Alkmaar, the Netherlands. ^[4] Department of Medical Oncology, Amsterdam UMC, Location VUmc, Cancer Center Amsterdam, Amsterdam, The Netherlands. ^[5] Department of Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands. ^[6] Department of Epidemiology and Data Science, Amsterdam University Medical Centers, Location VUmc, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. ^[7]

关键词 Colorectal cancer Colorectal liver metastases (CRLM)Neoadjuvant systemic therapy Randomized controlled trial (RCT)Surgery Thermal ablation