Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

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作者： Brigitt,Raux ^[1] ; Karly A,Buchan ^[1] ; James,Bennett ^[1] ; Thomas,Christott ^[1] ; Matthew S,Dowling ^[2] ; Gillian,Farnie ^[3] ; Oleg,Fedorov ^[1] ; Vicki,Gamble ^[3] ; Carina,Gileadi ^[3] ; Charline,Giroud ^[1] ; Kilian V M,Huber ^[1] ; Magdalena,Korczynska ^[4] ; Chris,Limberakis ^[2] ; Arjun,Narayanan ^[4] ; Dafydd R,Owen ^[4] ; Laura Díaz,Sáez ^[1] ; Ingrid A,Stock ^[2] ; Allyn T,Londregan ^[5]

作者单位： Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. ^[1] Pfizer Worldwide Research and Development, Groton, CT 06340, USA. ^[2] Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. ^[3] Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA. ^[4] Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA. Electronic address: allyn.t.londregan@pfizer.com. ^[5]

关键词 Chemical probe Crystallography MLLT1 MLLT3 YEATS domain

主题词人类(Humans);核蛋白质类(Nuclear Proteins);组蛋白类(Histones);药物发现(Drug Discovery);肿瘤蛋白质类(Neoplasm Proteins);转录因子(Transcription Factors)

DOI 10.1016/j.bmcl.2023.129546

PMID 37944866

发布时间 2024-01-10

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